孙梅好

作者:来源:发布时间:2017-04-14

个人简介

孙梅好,男,1973年12月出生,山东省诸城人,现为浙江师范大学化学与生命科学学院教授、硕士生导师


学习经历

1992.9-1996.9  山东师范大学生命科学学院生物系获理学学士,生物学教育专业

1996.9-2002.3  中科院上海植物生理生态研究所获理学博士学位,植物学专业

2002.3-2008.9  赴美国爱因斯坦医学院生物化学系、微生物与免疫学系,博士后


工作简历

2002.3-2008.9  美国爱因斯坦医学院生物化学系、微生物与免疫学系,博士后

2008.9-至今   浙江师范大学化学与生命科学学院任教

校聘教授(2008.9)/研究员(2009.12)/教授(2011.12),硕导(2009.5)


学术兼职

浙江省生物工程学会会员

浙江省植物生理学会会员


人才梯队、荣誉

浙江省高校中青年学科带头人(2013年)


研究领域及成果

长期从事生物化学与分子生物学专业领域的研究,在该领域取得一定成绩,在《Journal of Biological Chemistry》、《Biochemistry》等杂志上发表论文十余篇。

代表性论文、论著

1.论文“The human estrogen sulfotransferase: a half-site reactive enzyme” 2010年4月发表于《Biochemistry》第49卷23期;

2.论文“Channeling in sulfate activating complexes” 2006年9月发表于《Biochemistry》第45卷38期;

3.论文“The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis” 2005年3月发表于《J Biol Chem》第280卷9期;

4.论文“Anatomy of an energy-coupling mechanism--the interlocking catalytic cycles of the ATP sulfurylase-GTPase system” 2005年10月发表于《Biochemistry》第44卷42期;

5.论文“Distribution of water channel protein RWC3 and its regulation by GA and sucrose in rice (Oryza sativa)” 2004年9月发表于《Acta Bot Sin》第46卷9期;

6.论文“A simple method for in situ hybridization to RNA in guard cells of Vicia faba L.: the expression of aquaporins in guard cells” 2001年6月发表于《Plant Mol Biol Rep》第19期;

7.论文“硫酸盐活化复合体的分类及其功能” 2011年4月发表于《生命的化学》第31卷2期。

代表性科研项目

1.2011-2013,国家自然科学基金一般项目-“水稻白叶枯病菌(PXO99)avrXa21成熟机理及其生理功能研究(31070055)”;

2.2009-2011,国家自然科学基金青年基金项目-“球形红细菌硫活化酶底物通道机理及功能研究(30800019)”;

3.2010-2013,浙江省钱江人才计划-“硫活化酶腺苷磷酰硫酸通道的分析及其在水稻中的应用(2010R10088)”;

4.2010-2012,教育部留学归国人员科研启动基金-“硫活化酶复合体底物通道的结构基础分析”;

5.2009-2011,浙江省自然科学基金一般项目-“球形红细菌硫酸盐活化酶复合体代谢硒酸盐的研究(Y3090546)”。

学术报告

1.2013.5,在全国第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会作学术报告《一种基于酵母3’,5’二磷酸核苷酸酶的亲和纯化体系》;

2.2006.10,在纽约科学院化学生物学讨论会上做学术报告《Half-of-Sites Reactivity of Human Estrogen Sulfotransferase》。


近三年教学情况

为本科生主讲课程有《生物化学》、《生物学专业英语》、《生物工程下游技术》,指导本科生论文16篇;为研究生开设《高级生物化学》、《生命科学进展》等课程,指导培养硕士研究生6名。


Profile

Meihao Sun, Male, was born in Zhucheng, Shandong Province in Dec.1973. Professor, graduate students (Master) supervisor at College of Chemistry and Life Sciences, Zhejiang Normal University.


Education Background

11992.9-1996.9   Biology Dept., Shandong Normal University, B.S. degree, Major in Biology Education;

1996.9-2002.3  Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Ph.D. degree, Major in Plant Science;

2002.3-2008.9   Biochemistry Dept., Microbiology and Immunology Dept., Albert Einstein College of Medicine, Postdoc, Research Associate.


Work Experiences

2002.3-2008.9   Biochemistry Dept., Microbiology and Immunology Dept., Albert Einstein College of Medicine, Postdoc, Research Associate.

2008.9—present Teaching at College of Chemistry and Life Science, Zhejiang Normal University.

Professor (University, 2008.9) /Professor (2009.12), graduate students (Master) supervisor (2009.5).


Other Academic Positions/Memberships

Member of Society of Plant Physiology of Zhejiang Province

Member of Society of Bioengineering of Zhejiang Province


Honorable Titles and Awards

Academic Leader for young and middle aged scientists in Zhejiang Colleges and Universities (2013)


Research Field and Achievements

Focusing on the related areas of Biochemistry and Molecular Biology, especially the mechanism of sulfur metabolism and functions of sulfur containing compounds in cells. Published 18 articles in Journals such as “Journal of Biological Chemistry” and “Biochemistry”.

Representative Works

1. The human estrogen sulfotransferase: a half-site reactive enzyme [J]. Biochemistry, 2010, 49(23): 4779-4785.

2. Channeling in sulfate activating complexes [J]. Biochemistry, 2006, 45(38): 11304-11311. 1/2

3. The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis [J]. J Biol Chem, 2005, 280(9): 7861-7866.

4. Anatomy of an energy-coupling mechanism--the interlocking catalytic cycles of the ATP sulfurylase-GTPase system [J]. Biochemistry, 2005, 44(42): 13941-13948.

5. Distribution of water channel protein RWC3 and its regulation by GA and sucrose in rice (Oryza sativa) [J]. Acta Bot Sin, 2004, 46(9): 1056-1064.

6. A simple method for in situ hybridization to RNA in guard cells of Vicia faba L.: the expression of aquaporins in guard cells [J] Plant Mol Biol Rep, 2001, 19: 129-135.

7. Classification and functions of sulfate activating complexes [J] Chemistry Life, 2011,31(2):252-257

Research Projects

1. 2011-2013,National Science Foundation Grant-“Mechanism and function studies on avrXa21from Xanthomonas oryzae (PXO99)”.

2. 2009-2011,National Science Foundation Grant for Young Investigators-“Mechanism and function studies for substrate channeling in Sulfate Activating Complex from Rhodobacter sphaeroides”.

3. 2010-2013,Qianjiang Talent Project of Zhejiang Province-“Analysis on the 5’-phosphosulfate adenosine channeling and its application on rice”.

4. 2010-2012,Research Foundation for Returned Scholars from the Ministry of Education of China.-“Analysis of structural basis on 5’-phosphosulfate adenosine channeling”.

5. 2009-2011,Natural Science Foundation of Zhejiang Province-“Studies on activation of selenate by sulfate activating complex from Rhodobacter sphaeroides”.

Reports

1. 2013.5, 11th National colloquium on Enzymology and symposium for Memorials of Professor Zou Chenglu on his birth of 90th anniversary, Development of one purification system based on yeast 3’, 5’-bisphosphate nucleotidase.

2. 2006.10 The Chemical Biology Discussion Group of The New York Academy of Sciences, “Half-of-Sites Reactivity of Human Estrogen Sulfotransferase”.


Teaching and Supervision during Last 3 Years

Courses for undergraduate include Biochemistry, English for Biological Major Students, and Downstream Processing of Bioengineering. Supervised 16 undergraduate students’ thesis. Courses for graduate students include Advanced Biochemistry, and Research Progress on Biological Science, etc., Supervised 6 graduate students.