张应烙

作者:来源:发布时间:2017-04-14

个人简介

张应烙,男,1976年2月出生,江西省上饶县人,现为浙江师范大学化学与生命科学学院副教授、硕士生导师


学习经历

1996.9-2000.7  江西农业大学植物保护系获农学学士,植物保护专业

2000.9-2003.7  西北农林科技大学植物保护学院获农学硕士学位,植物病理专业

2005.9-2008.7  南京大学生命科学学院获理学博士学位,生物学专业


工作简历

2008.8-至今   浙江师范大学化学与生命科学学院任教

讲师(2008.9)/副教授(2010.9)硕导(2011.1)


人才梯队、荣誉

浙江省高校中青年学科带头人(2013.5)

浙江省151人才工程第三层次入选者(2013.9)


研究领域及成果

长期从事天然药物化学专业领域的研究,在该领域取得一定成绩,在《Journal of the American Chemical Society》、《Angewandte Chemie International Edition》等杂志上发表论文20余篇,获得授权发明专利4件。

代表性论文、论著

1.Zhang, Y. L.; Zhang, J.; Jiang, N.; Lu, Y. H.; Wang, L.; Xu, S. H.; Wang, W.; Zhang, G. F.; Xu, Q.; Ge, H. M.; Ma, J.; Song, Y. C.; Tan, R. X. Immunosuppressive polyketides from the mantis-associated Daldinia eschscholzii. Journal of the American Chemical Society, 2011, 133, 5931-5940.

2. Zhang, Y. L.; Ge, H. M.; Zhao, W.; Dong, H.; Xu, Q.; Li, S. H.; Li, J.; Zhang, J.; Song, Y. C.; Tan, R. X. Unprecedented immunosuppressive polyketides from Daldinia eschscholzii, a mantis-associated fungus. Angewandte Chemie International Edition, 2008, 47, 5823 –5826.

3. Zhang, Y. L.*; Kong, L. C.; Jiang, D. H.; Yin, C. P.; Cai, Q. M.; Chen, Q.; Zheng, J. Y. Phytotoxic and antifungal metabolites from Curvularia sp. FH01 isolated from the gut of Atractomorpha sinens.Bioresource Technology, 2011, 102, 3575–3577.

4. Zhang, Y. L.*; Li, S.; Jiang, D. H.; Kong, L. C.; Zhang, P. H.; Xu, J. D. Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02. Journal of Agricultural and Food Chemistry, 2013, 61, 1521−1524.

5. Zhang, Y. L.*; Li, S.; Yin, C. P.; Jiang, D. H.; Yan, F. F.; Xu, T. Response surface optimisation of aqueous enzymatic oil extraction from bayberry (Myrica rubra) kernels. Food Chemistry,2012, 135, 304-308.

6.Zhang, Y. L.*; Yin, C. P.; Kong, L. C.; Jiang, D. H. Extraction optimization, purification and major antioxidant component of red pigments extracted from Camellia japonica. Food Chemistry, 2011, 129, 660-664.

7. Zhang, Y. L.*; Kong, L. C.; Yin, C. P.; Jiang, D. H.; Jiang, J. Q.; He, J.; Xiao, W. X. Extraction optimization by response surface methodology, purification and principal antioxidant metabolites of red pigments extracted from bayberry (Myrica rubra) pomaceLWT-Food Science &Technology , 2013, 51, 343-347.

8. Zhang, Y. L.; Ge, H. M.; Li, F.; Song, Y. C.; Tan, R. X. New phytotoxic metabolites from Pestalotiopsis sp. HC02, a fungus residing in Chondracris rosee gut. Chemistry & Biodiversity,2008, 5, 2402-2407.

9. 李帅, 蒋建泉, 胡癸峰, 张应烙*. 杨梅渣红色素酸水提取和精制工艺. 食品科学, 2012, 33(24): 21-25.

10. 张应烙*, 尹彩萍, 叶圣涛, 缪仁挺. 棉蝗肠道真菌Phoma sp. HC03除草和免疫抑制成分研究, 天然产物研究与开发, 2010, 22(4): 600-602.

代表性科研项目

1.2013-2016,国家自然科学基金面上项目-“蜻蜓肠道菌的免疫抑制成分及其构效关系研究”;

2.2013-2016,国家自然科学基金面上项目-“蜻蜓肠道菌的免疫抑制成分及其构效关系研究”;

3.2011-2013,国家自然科学基金青年基金项目-“白蚁共生放线菌的抗菌成分研究”;

4.2010-2012,浙江省科技厅公益性技术应用研究计划项目-“杨梅残渣的增值加工关键性技术研究”;

5.2010-2012,浙江省自然科学基金项目面上项目-“白蚁共生放线菌的抗菌成分及其构效关系研究”。

学术报告

1.2013.10,在全国微生物学会学术年会作学术报告《昆虫共生菌的活性次生代谢产物》;

2.2013.8,在全国第六届植物化感作用研讨会作学术报告《昆虫共生菌的次生代谢产物及其功能》;

3.2013.8,在全国第六届植物化感作用研讨会作学术报告《昆虫共生菌的次生代谢产物及其植保功能》;

4.2012.11,在第十二届全国中药和天然药物学术研讨会作学术报告《螳螂相关菌Daldinia eschscholzii TL01中的免疫抑制聚酮化合物》;

5. 2012.8,在第九届全国化学生态学学术研讨会作学术报告《昆虫共生菌的次生代谢产物及其生态功能》;

6. 2011.11,在全国药物化学学术会议作学术报告《昆虫共生菌-新型药物分子的广泛来源》;

7.2011.8在第十届全国药用植物及植物药学术研讨会作学术报告《昆虫共生菌-新药物分子的重要来源》。


近三年教学情况

为本科生主讲课程有《微生物学实验》、《天然药物化学》、《文献检索与论文写作》,指导本科生论文25篇;为研究生开设《植物化学》和《生命科学前沿专题》等课程,指导培养硕士研究生3名。


Profile

Title: Associate Professor in Biology, Zhejiang Normal University

Location: 10-419

Mail Code: 321004

Research Area: Natural Product Chemistry; Bioorganic


Education Background

Ph.D.  2005.9-2008.7 Natural Product Chemistry, Nanjing University

M.S.   2000.9-2003.7 Phytopathology, School of Plant Protection, Northwest A & F University.

B.S.       1996.9-2000.7 Plant Protection, Department of Plant Protection, Jiangxi Agricultural University


Research Field and Achievements

A primary goal of natural products research is to understand the chemistry of insect-associated microbes. Using bioassay-guided separation contributes us to the discovery of natural products potent against plant diseases, weeds as well as human diseases. Our laboratory search for new active metabolites incorporates elements of structure elucidation but there are other areas to this research, including questions in the fields of microbial natural products biosynthesis and chemical ecology.U

Representative Works

1. Zhang, Y. L.; Zhang, J.; Jiang, N.; Lu, Y. H.; Wang, L.; Xu, S. H.; Wang, W.; Zhang, G. F.; Xu, Q.; Ge, H. M.; Ma, J.; Song, Y. C.; Tan, R. X. Immunosuppressive polyketides from the mantis-associated Daldinia eschscholzii. Journal of the American Chemical Society, 2011, 133, 5931-5940.

2. Zhang, Y. L.; Ge, H. M.; Zhao, W.; Dong, H.; Xu, Q.; Li, S. H.; Li, J.; Zhang, J.; Song, Y. C.; Tan, R. X. Unprecedented immunosuppressive polyketides from Daldinia eschscholzii, a mantis-associated fungus. Angewandte Chemie International Edition, 2008, 47, 5823 –5826.

3. Zhang, Y. L.*; Kong, L. C.; Jiang, D. H.; Yin, C. P.; Cai, Q. M.; Chen, Q.; Zheng, J. Y. Phytotoxic and antifungal metabolites from Curvularia sp. FH01 isolated from the gut of Atractomorpha sinens. Bioresource Technology, 2011, 102, 3575–3577.

4. Zhang, Y. L.*; Li, S.; Jiang, D. H.; Kong, L. C.; Zhang, P. H.; Xu, J. D. Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02. Journal of Agricultural and Food Chemistry, 2013, 61, 1521−1524.

5. Zhang, Y. L.*; Li, S.; Yin, C. P.; Jiang, D. H.; Yan, F. F.; Xu, T. Response surface optimisation of aqueous enzymatic oil extraction from bayberry (Myrica rubra) kernels. Food Chemistry,2012, 135, 304-308.

6. Zhang, Y. L.*; Yin, C. P.; Kong, L. C.; Jiang, D. H. Extraction optimization, purification and major antioxidant component of red pigments extracted from Camellia japonica. Food Chemistry, 2011, 129, 660-664.

7. Zhang, Y. L.*; Kong, L. C.; Yin, C. P.; Jiang, D. H.; Jiang, J. Q.; He, J.; Xiao, W. X. Extraction optimization by response surface methodology, purification and principal antioxidant metabolites of red pigments extracted from bayberry (Myrica rubra) pomace. LWT-Food Science & Technology, 2013, 51, 343-347.

8. Zhang, Y. L.; Ge, H. M.; Li, F.; Song, Y. C.; Tan, R. X. New phytotoxic metabolites from Pestalotiopsis sp. HC02, a fungus residing in Chondracris rosee gut. Chemistry & Biodiversity,2008, 5, 2402-2407.

9. Fang, W.; Ji, S.; Jiang, N.; Wang, W.; Zhao, G. Y.; Zhang, S.; Ge, H. M.; Xu, Q.; Zhang, A. H.; Zhang, Y. L.; Song, Y. C.; Zhang, J.; Tan, R. X. Naphthol radical couplings determine structural features and enantiomeric excess of dalesconols in Daldinia eschscholzii. Nature Communications, 2012, 3, 1039.

Research Projects

1. National Nature Science Foundation of China (2013-2016)

Project title: Immunosuppressive metabolites produced by the dragonfly symbionts and their structure-activity relationships.

2. National Nature Science Foundation of China (2011-2013)

Project title: Antimicrobial metabolites from the termite symbionts.

3. Zhejiang Provincial Natural Science Foundation of China (2010-2012);

Project title: Antimicrobial metabolites produced by the termite symbionts and their structure-activity relationships.

4. Welfare Technology Applied Research Project of Zhejiang Province (2010-2012).

Project title: Value-added processing technology of bayberry residues.


Teaching and Supervision during Last 3 Years

1. Experiment of microbiology, Natural product chemistry and Literatures searching and scientific papers writing for undergraduate students.

2.  Phytochemistry and Frontier special topics of life sciences for postgraduate students.

3.  Thesis advisor for 25 undergraduates and 3 postgraduate in nearly three years.


Contact

Email: ylzhang@zjnu.cn

URL: http://sky.zjnu.net.cn/E_ReadNews.asp?NewsID=4925