张可伟(遗传学)

作者:来源:发布时间:2017-04-14

个人简介

张可伟,男,理学博士,1977 年5月出生,山东枣庄人,现为浙江师范大学化学与生命科学学院特聘教授,硕士生导师。Email: kwzhang@zjnu.cn


学习经历

1996.9-2000.7 山东农业大学生科院理学学士,生物技术专业

2000.9-2003.7 山东农业大学生科院理学硕士,生化与分子生物学专业

2003.9-2006.7 中国科学院遗传发育所理学博士,遗传学专业

2006.7-2009.7 美国康奈尔大学农业与生命科学学院博士后

2009.7-2013.12 美国能源部布鲁克海文国家实验室生物系研究助理。


工作简历

2013.12-2014.4 浙江师范大学生化学与生命科学学院校特聘教授;

2014.5-至今 浙江师范大学生化学与生命科学学院省特聘教授。


学术兼职

浙江师范大学生化学院学术委员会委员;

中国植物生理与分子生物学会(CSPB)会员;

美国植物生物学家学会(ASPB)会员。


人才梯队、荣誉

“钱江学者” 特聘教授(2014.5);

美国布鲁克海文国家实验室Spotlight Award(2010.9);

中国科学院地奥奖学金一等奖(2006.7)。


研究领域及成果

张可伟博士长期从事植物衰老相关激素和次生代谢领域的研究工作,在该领域取得了重要进展,首次鉴定了第一个植物细胞分裂素长距离转运蛋白AtABCG14和第一个植物水杨酸羟化酶S3H。在《Nature Communications》、《PNAS》、《The Plant Cell》、《科学通报》等国内外著名杂志上发表论文10余篇,其中第一作者8篇(总影响因子50多);获国家发明专利1项,申请美国发明专利1项。研究成果受到国内外同行的关注,多次被国际权威学术杂志 (Faculty 1000等)和学术媒体(Science Daily等)推荐。张可伟实验室目前主要研究内容包括:1)细胞分裂素运输在植物生长发育和衰老中的作用机制;2)水杨酸代谢在植物衰老和抗病中的作用机制;3)水稻和园艺作物的基因工程改良。

代表性论文、论著

1.Zhang, K., Novak, O., Wei, Z., Gou, M., Zhang, X.,Yu, Y., Yang, H., Cai, Y., Strnad, M., and Liu C-J*.Arabidopsis ABCG14 protein controls the acropetal translocation of root-synthesized cytokinins. Nature Communications,2014, 10.1038/ncomms4274. 第一作者, Faculty of 1000推荐(http://f1000.com/prime/718272723)

2.Zhang, K.,Halitschke, R., Yin, C., Liu,C-J, Gan, S*. Salicylic acid 3-hydroxylase regulates Arabidopsis leaf longevity by mediating SA catabolism. PNAS,2013, 110 : 14807–14812. 第一作者, Faculty of 1000推荐(http://f1000.com/prime/718077385)

3.Zhang, K§.,Bhuiya, M.-M§., Pazo, J., Miao, Y., Kim, H., Ralph, J. and Liu, C.-J.*.An engineered monolignol 4-O-methyltransferase depresses lignin biosynthesis and confers novel metabolic capability in Arabidopsis. Plant Cell, 2012, 24: 3135-3152. (§同等贡献)第一作者

4.Zhang, K.,and Gan, S*.An abscisic acid-AtNAP transcription factor-SAG113 protein phosphatase 2C regulatory chain for controlling dehydration in senescing Arabidopsis leaves. Plant Physiol, 2012, 158: 961-969. 第一作者

5.Zhang, K., Xia, X., Zhang, Y. and Gan, S*.An ABA-regulated and Golgi-localized protein phosphatase controls water loss during leaf senescence in Arabidopsis. Plant J, 2012, 69: 667-678. 第一作者

6.Zhang, K§., Qian, Q§., Huang, Z., Wang, Y., Li, M., Hong, L., Zheng, D., Gu, M., Chu,C., and Cheng, Z.* GOLD HULL AND INTERNODE2 Encodes a Primarily Multifunctional Cinnamyl-Alcohol Dehydrogenase in Rice. Plant Physiol, 2006, 140: 972-983 (§同等贡献)第一作者

7.Zhang, K., Wang, J., Yang, G., Guo, X., Cui, D., Wen, F., Zheng, C.* Isolation of a strong matrix attachment region (MAR) and identification of its function in vitro and in vivo, Chinese Science Bulletin(科学通报), 2002, 47: 1999-2005. 第一作者

8.Zhang,K., Wang, J.,Zheng,C*.The Potential Role of Nuclear Matrix Attachment Regions (MARs) in Regulation of Gene Expression, 生物工程学报, 2004, 20(1):6-9. 第一作者

代表性科研项目(主持省部级及以上):

2015-2018,国家自然科学基金面上项目(31470370)-“拟南芥ABCG14细胞分裂素转运复合体的鉴定和作用机理研究”,90万元。

学术报告(国际或全国性会议上):

1.2014年8月5-8日,应邀在中国植物生理与植物分子生物学学会第十一次会员代表大会暨全国学术年会作《AtABCG14控制细胞分裂素的向顶运输》学术报告;

2.2014年7月2-5日,应邀在第三届国际植物代谢大会作《A Brake of Leaf Senescence:Salicylic acid 3-hydroxylase regulates Arabidopsis longevity by mediating salicylic acid catabolism》学术报告。


近三年教学情况(含本科教学、研究生教学):

为本科生主讲课程有《高级生物化学》、《生物化学实验》,指导本科生论文3篇;现指导培养硕士研究生3名,本科生5名。


Profile

Dr. Kewei Zhang was born in Zaozhuang, Shandong , China in May, 1977. He is currently taking a position of Qianjiang Distinguished Professor in College of Chemistry and life sciences in Zhejiang Normal University. Email: kwzhang@zjnu.cn


Education Background

09/2003-07/2006, Ph.D in Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China;
09/2000-07/2003, M.S. in Biochemistry & Molecular Biology, College of Life Sciences, Shandong Agricultural University, Taian, Shandong, China;
09/1996.9-07/2000, B.S. in Biotechnogy, College of Life Sciences, Shandong Agricultural University, Taian, Shandong, China.


Work Experiences

12/2013-now Qianjiang Distinguished Professor in Zhejiang Normal University, Jinhua, Zhejiang, China; 07/2009-12/2013 Research Associate, Department of Biosciences, Brookhaven National Laboratory, Upton, NY, USA; 07/2006-07/2009 Postdoc, Department of Horticulture, Cornell University, Ithaca, NY, USA.


Other Academic Positions/Memberships

Member of Academic Committee at College of Chemistry and Life Sciences in Zhejiang Normal University;Member of Chinese Society of Plant Biology (CSPB);
Member of American Society of Plant Biologist (ASPB).


Honorable Titles and Awards

Qianjiang Distinguished Scholar Award of Zhejiang Province (05/2014);
Spotlight Award in Brookhaven National Laboratory (09/2010);
Di’Ao Scholarship (first grade) in Chinese Academy of Sciences (07/2006).


Research Field and Achievements

Dr. Kewei Zhang has been focusing on hormonal regulation of leaf senescence and plant second metabolism since 2003. The major achievements of Dr. Zhang are (1) The characterization of first cytokinin transporter (AtABCG14) for long-distance transportation (Nature Communications,2014, 10.1038/ncomms4274); (2) The characterization of the first salicylic acid 3-hydroxylase and elucidation of the mechanism in controlling salicylic acid homoeostasis (PNAS, 2013, 110 : 14807–14812) ; (3) The identification of  a regulation cascade of ABA-AtNAP-SAG113 which regulates water loss in leaf senescence (Plant Physiol, 2012, 158: 961-969; Plant J, 2012, 69: 667-678);  (4) The map-based cloning of the rice OsCAD gene and protein engineering of the MOMT4 which regulate lignin precursor (second metabolite) biosynthesis (Plant Cell, 2012, 24: 3135-3152;Plant Physiol, 2006, 140: 972-983). The publications of AtABCG14 and S3H were strongly recommended by “Faculty of 1000” and reported by “Science Daily” respectively. Currently, the research interests in Dr. Zhang’s lab include (1) Cytokinin transportation and its roles in plant development and leaf senescence; (2) SA metabolism and its roles in leaf senescence and plant pathogen responses; (3) Molecular breeding of rice and horticultural crops.


Representative Works

1) Zhang, K., Novak, O., Wei, Z., Gou, M., Zhang, X.,Yu, Y., Yang, H., Cai, Y., Strnad, M., and Liu C-J*.Arabidopsis ABCG14 protein controls the acropetal translocation of root-synthesized cytokinins. Nature Communications,2014, 10.1038/ncomms4274. This article was recommended by Faculty of 1000 http://f1000.com/prime/718272723)
2) Zhang, K.,Halitschke, R., Yin, C., Liu,C-J, Gan, S*. Salicylic acid 3-hydroxylase regulates Arabidopsis leaf longevity by mediating SA catabolism. PNAS,2013, 110 : 14807–14812. This article was recommended by Faculty of 1000 (http://f1000.com/pri me/718077385)
3) Zhang, K§.,Bhuiya, M.-M§., Pazo, J., Miao, Y., Kim, H., Ralph, J. and Liu, C.-J.*.An engineered monolignol 4-O-methyltransferase depresses lignin biosynthesis and confers novel metabolic capability in Arabidopsis. Plant Cell, 2012, 24: 3135-3152. (§Equal contribution)
4) Zhang, K.,and Gan, S*.An abscisic acid-AtNAP transcription factor-SAG113 protein phosphatase 2C regulatory chain for controlling dehydration in senescing Arabidopsis leaves. Plant Physiol, 2012, 158: 961-969.
5) Zhang, K., Xia, X., Zhang, Y. and Gan, S*.An ABA-regulated and Golgi-localized protein phosphatase controls water loss during leaf senescence in Arabidopsis. Plant J, 2012, 69: 667-678.
6) Zhang, K§., Qian, Q§., Huang, Z., Wang, Y., Li, M., Hong, L., Zheng, D., Gu, M., Chu,C., and Cheng, Z.* GOLD HULL AND INTERNODE2 Encodes a Primarily Multifunctional Cinnamyl-Alcohol Dehydrogenase in Rice. Plant Physiol, 2006, 140: 972-983 (§Equal contribution)
7) Zhang, K., Wang, J., Yang, G., Guo, X., Cui, D., Wen, F., Zheng, C.* Isolation of a strong matrix attachment region (MAR) and identification of its function in vitro and in vivo, Chinese Science Bulletin, 2002, 47: 1999-2005.
8) Zhang,K., Wang, J.,Zheng,C*.The Potential Role of Nuclear Matrix Attachment Regions (MARs) in Regulation of Gene Expression, Chinese Journal of Biotechnology, 2004, 20(1):6-9.


Research Projects

2015-2018 The National Natural Science Foundation (NSF) of China (31470370), PI, 90,000 RMB.


Invited Talks in Conference

July 2-5, 2014 A Brake of Leaf Senescence:Salicylic acid 3-hydroxylase regulates Arabidopsis longevity by mediating salicylic acid catabolism, The 3rd International Conference of Plant Metabolism, Xiamen, China;Aug 5-8, 2014 The AtABCG14 is essential for cytokinin long-distance transportation, The 11th Annual Conference of Chinese Society of Plant Biology, Guiyang, China.


Teaching and Supervision during Last 3 Years

I teach Advanced Biochemistry and Biochemistry Experiments for undergraduate students. I am supervising three graduate students and 5 undergraduate students.